Renal organic cation transporter ADMET Feature Prediction

The renal organic cation transporter is important for the uptake or efflux of cationic drugs ³. Various subtypes of this transporter exist, which mediate the transport of organic cations in the kidney. Clinically significant drug interactions in the kidney have been attributed to the inhibition of renal organic cation transporters ⁴. It is therefore important to be aware of which drugs may be renal organic cation transporter inhibitors. This information can be found in the "Predicted ADMET features" section of a drug entry.

DrugBank automatically retrieves information from admetSAR database, using a table format to display various predicted properties of a drug. This database predicts the absorption, distribution, metabolism, excretion, and toxicity of drugs (ADMET) ¹. One prediction made by admetSAR is whether a substance inhibits or does not inhibit the renal organic cation transporters, which may include transporters such as OCTN1, OCTN2, OCT1, OCT2, OCT3 ^2,3. Drugs are classified as "inhibitors" or "non-inhibitors" of these transporters.